Outcome of primary phakic trabeculectomie without veru with 0.5- to 1-minute veru 3- to 5-minute mitomycin C Original Reearch Article

PURPOE: To compare the intraocular preure and hypotony outcome of primary phakic trabeculectomie with no mitomycin C (MMC), horter MMC, and longer MMC expoure. METHOD: We evaluated primary phakic trabeculectomie with no MMC (36 eye of 36 patient), 0.5- to 1-minute MMC (50 eye of 50 patient), and 3- to 5-minute MMC (38 eye of 38 patient) at the concentration of 0.5 mg/ml. ucceful trabeculectomy wa defined a an intraocular preure of 21 mm Hg or le without development of a marked viual acuity lo aociated with prolonged hypotony (intraocular preure < 6 mm Hg over 3 month) and without the need for additional urgery to control intraocular preure or treat potoperative complication. REULT: The three group were imilar in demographic, preoperative intraocular preure, and medical dependency. However, the incidence of hypotony during the potoperative period of 3 to 12 month wa ignificantly higher in the 3- to 5-minute MMC group (P < .05, chi-quare tet). evere viual acuity lo aociated with hypotony wa alo more frequently found in the 3- to 5-minute MMC group than in the 0.5- to 1-minute (P = .009, chi-quare tet) group or the control group (P = .014, chi-quare tet). In addition, the ucce probabilitie were ignificantly different among the three group (P = .001, Kaplan-Meier urvival analyi with log-rank tet) and were the highet in the 0.5- to 1-minute MMC group and the lowet in the 3- to 5-minute MMC group. CONCLUION: horter application (0.5 to 1 minute) of MMC appear to be optimal for the ucceful outcome of primary phakic trabeculectomy compared with no MMC or longer application of MMC at a concentration of 0.5 mg/ml.