Progreion of defect in the central 10-degree viual field of patient with retiniti pigmentoa and choroideremia Original Reearch Article

Purpoe: To determine the progreion of defect in the central 10-degree viual field in patient with retiniti pigmentoa and choroideremia by mean of univariate linear regreion with repect to the mean deviation. Method: In a retropective tudy, reult of automated tatic perimetry in the central 10-degree viual field were reviewed for patient with retiniti pigmentoa and choroideremia. Univariate linear regreion of mean deviation wa undertaken for each eye that had field data from at leat five tet in addition to the prior tatic perimetric experience during a period of 3.5 year or more. Data from 30 eye of 16 patient fulfilled eligibility requirement; the mean number of field wa 5.8 (range, five to 10) and the mean follow-up period wa 64 month (range, 42 to 97 month). Eye were claified a progreive if the regreion coefficient wa negative and ignificantly different from zero, with a P value of le than .05. Reult: Among 14 patient in whom both eye were eligible for univariate linear regreion analyi, a tatitically ignificant progreion wa demontrated in both eye in four patient, only in one eye in five patient, and in neither eye in five patient. One of two patient, in whom only one eye wa eligible for the tudy, howed ignificant progreion in the eye. Overall, 14 (47%) of 30 eye howed tatitically ignificant progreion with repect to the mean deviation. No eye howed ignificant improvement. Concluion: Automated tatic perimetry of the central 10-degree viual field meaured approximately once or twice a year demontrated the progreive nature of the dieae with the ue of univariate linear regreion of mean deviation in 47% of eye with retiniti pigmentoa and choroideremia during the follow-up period of 3.5 year or more. Thee reult may be ueful in undertanding the clinical coure of the dieae and couneling patient.