Factor V Leiden mutation i aociated with ocular involvement in Behçet dieae Original Reearch Article

PURPOE: Behçet dieae i a ytemic dieae of young adult characterized by venou occluion in both the deep venou and retinal circulation. In evere ocular dieae, blindne may occur depite immunouppreive treatment. The mot common inherited rik factor for the development of idiopathic venou thromboi i the preence of the Factor V (FV Leiden) mutation, which confer reitance to activated protein C. The aociation of FV Leiden with Behçet dieae ha been reported, but it influence on ocular dieae i not known. We therefore invetigated the prevalence of thi mutation in patient with Behçet dieae to determine it contribution to the preence and everity of ocular dieae. METHOD: One hundred and ix Middle Eatern patient atifying international criteria, and 120 healthy control ubject without a hitory of venou thromboi were included in the tudy, and patient underwent tandard examination by two ophthalmologit with an interet in Behçet dieae. Genomic DNA wa extracted from peripheral blood leukocyte and creened for the FV Leiden mutation with the polymerae chain reaction method with equence-pecific primer (PCR-P). REULT: FV Leiden wa detected in 19% (23/120) of the control population compared with 27% (29/106) of all patient with Behçet dieae (P = .13). However, among patient with Behçet dieae who had ocular dieae (75/106), the prevalence of FV Leiden wa ignificantly higher (32%) than it wa in control ubject (P = .04). Furthermore, ocular patient with Behçet dieae in whom retinal occluive dieae wa oberved (25/75) had the highet expreion of FV Leiden (44%). CONCLUION: Thee data ugget that FV Leiden may be an additional rik factor for the development of ocular dieae and, in particular, retinal vao-occluion, and it may contribute to the poor viual outcome in thee patient.