Effect of eyelid botulinum toxin injection on lacrimal drainage

PURPOE: To determine the effect of eyelid botulinum toxin injection on the lacrimal drainage and to ae the ue of botulinum toxin in dry eye condition. METHOD: Propectively, three tet group were examined and one lacrimal ytem invetigated in each peron in each group. Botulinum toxin A (3.75 IU) wa injected into the medial part of 13 lower eyelid of 13 normal tet ubject and the medial part of nine lower eyelid in nine patient with dry eye. A doe of 2.5 IU wa injected into the medial part of 10 lower eyelid and the medial part of 10 upper eyelid of 10 patient with dry eye. The drop tet wa ued to determine the lacrimal drainage capacity and the blink output, before and after the injection. The ubjective effect of the botulinum toxin injection on eye comfort wa invetigated. REULT: Three week after lower eyelid botulinum toxin injection, the mean blink output wa reduced to 64% (1.19 of 1.87; P< .001) and 70% (0.94 of 1.35; P< .001) of the baeline value in the group of normal ubject and patient, repectively. After injection in both the upper and lower eyelid, the mean blink output wa reduced to 38% (0.54 of 1.41; P< .001) of the baeline value. The patient with dry eye reported an improved eye comfort in ix of nine cae after injection in the lower eyelid and in even of 10 cae after injection in both the upper and lower eyelid. Advere effect included one cae of increaed dicomfort for 3 week after injection. CONCLUION: Injection of botulinum toxin into the medial part of the eyelid decreaed the lacrimal drainage, uggeting a new way to treat dry eye condition. Further tudie are required to ae the clinical value of thi treatment.