Hyperhomocyteinemia: a rik factor for central retinal vein occluion

PURPOE: Previou tudie have documented that elevated plama homocyteine level i a rik factor for vacular dieae. Thi tudy wa performed to determine whether hyperhomocyteinemia i a rik factor for central retinal vein occluion. METHOD: In a cae-control tudy, data from 74 patient with documented central retinal vein occluion were reaeed. Control ubject conited of individual referred to the ame clinic for aement of a nonretinal vacular dieae. Hyperhomocyteinemia wa defined a a total plama homocyteine level above the 95th percentile in the control group. REULT: The mean total plama homocyteine level wa 11.58 ± 4.67 μmol/l (range, 5–26 μmol/l) for cae, and 9.49 ± 2.65 μmol/l (range, 5–20 μmol/l) for control ubject. Of the 74 patient with a central retinal vein occluion, 16 (21.6%) had total plama homocyteine level above the 95th percentile in the control group (odd ratio, 6.53; 95% confidence interval, 1.81–23.50; P = .003). Hyperhomocyteinemia wa preent in five (55%) of the nine individual with bilateral dieae, nine (30%) of the 30 patient with ichemic occluion, and 45 (31%) of the 83 eye with evere viual lo. CONCLUION: Hyperhomocyteinemia i a rik factor for central retinal vein occluion and may ugget a poor prognoi in patient with central retinal vein occluion.