Author/Authors :
Marina Kniazeva، نويسنده , , Elia I. Trabouli، نويسنده , , Zhengya Yu، نويسنده , , uan T. tefko، نويسنده , , Michael B. Gorin، نويسنده , , Yin Y. hugart، نويسنده , , Jeffrey R. O’Connell، نويسنده , , Carrie J. Blachak، نويسنده , , Garry Cutting، نويسنده , , Min Han، نويسنده , , Kang Zhang، نويسنده ,
Abstract :
PURPOE: To report the localization of a gene cauing druen and macular degeneration in a previouly undecribed North American family.
METHOD: Genetic mapping tudie were performed uing linkage analyi in a ingle family with druen and atrophic macular degeneration.
REULT: The clinical manifetation in thi family ranged from fine macular druen in aymptomatic middle-aged individual to atrophic macular leion in two children and two elderly patient. We mapped the gene to chromoome 6q14 between marker D62258 and D61644.
CONCLUION: In a family with autoomal dominant druen and atrophic macular degeneration, the gene map to a 3.2-cM region on chromoome 6q14. Thi locu appear to be ditinct from, but adjacent to, the loci for cone-rod dytrophy 7 (CORD7) and North Carolina macular dytrophy (MCDR1). Future identification of the gene reponible for the dieae in thi family will provide a better undertanding of macular degeneration
