Aement of optic dik blood flow in patient with open-angle glaucoma

PURPOE: To characterize optic dik blood flow in patient with open-angle glaucoma compared with age-matched healthy control ubject. METHOD: In thi propective cro-ectional tudy, 90 eye of 90 patient with open-angle glaucoma and 61 eye of 61 age-matched healthy control ubject were evaluated. Flow in the optic dik cup and the neuroretinal rim were aeed with canning laer Doppler flowmetry. Fundu pulation amplitude in the cup and the macula were aeed with laer interferometry. Viual field mean deviation wa meaured with the Humphrey 30 to 2 program. REULT: Flow in the neuroretinal rim (−18%, P = .002), and in the cup (−46%, P < .001) and fundu pulation amplitude in the cup (−33%, P < .001) and in the macula (−24%, P < .001) were ignificantly lower in patient with open-angle glaucoma compared with healthy control ubject. A ignificant aociation between blood flow meaurement in the cup and fundu pulation amplitude in the cup wa oberved in both tudy cohort. A ignificant aociation wa alo oberved between the mean defect from viual field teting and ocular hemodynamic parameter. CONCLUION: Reduced optic dik perfuion in patient with open-angle glaucoma i evidenced from two independent method in the preent tudy. Moreover, our data indicate that reduced ocular blood flow in thee patient i linked to viual field change. It remain to be etablihed whether compromied optic dik and choroidal blood flow contribute to optic dik damage in glaucomatou eye or i a econdary functional phenomenon