Effect of dorzolamide timolol combination veru timolol 0.5% on ocular bloodflow in patient with primary open-angle glaucoma

PURPOE: Addition of dorzolamide to timolol in primary open-angle glaucoma how augmented reduction of intraocular preure. It i unknown a yet if addition of dorzolamide will alter hemodynamic. METHOD: Fifteen patient with primary open-angle glaucoma were placed on a medication-dependent 1-week to 4-week wahout that included maintenance on timolol. After wahout, baeline meaurement were taken (timolol). They were tudied after a month on timolol or dorzolamide-timolol (Coopt®; Merck, Inc, Whitehoue tation, New Jerey), with the econd drug preceded by another month of timolol maintenance and econd baeline meaurement. At each viit, viual function, intraocular preure, and ocular hemodynamic were monitored, including indocyanine green and fluorecein angiography and color Doppler imaging. REULT: Coopt® ignificantly reduced intraocular preure (14.7 to 13.4 mm Hg, P < .05) and increaed arteriovenou paage time (uperior temporal artery) of fluorecein dye (2.13 to 1.76 econd, P = .01) but had no effect on viual function. CONCLUION: When compared with timolol in primary open-angle glaucoma, Coopt® augment ocular tenion reduction and reduce the amount of time required for blood to pa through the uperior retinal vaculature.