Rik factor for failure of 5-fluorouracil needling reviion for failed conjunctival filtration bleb

PURPOE: To invetigate the rik factor for failure of 5-fluorouracil (5-FU) needling reviion, a ueful procedure for retoring a failed filtration bleb. DEIGN: Interventional cae erie. METHOD: Retropectively conducted tudy. ETTING: Intitutional. TUDY POPULATION: ixty-four eye of 64 conecutive glaucoma patient that underwent 5-FU needling reviion for failed filtering bleb following either trabeculectomy or phaco-trabeculectomy with or without adjunctive mitomycin C (MMC). OBERVATION PROCEDURE: Goldmann applanation tonometry, Kaplan-Meier urvival analyi, and Cox proportional hazard regreion analyi. MAIN OUTCOME MEAURE: ucceful outcome of the initial 5-FU needling reviion, arbitrarily defined a target intraocular preure (IOP) control with not more than two topical glaucoma medication and no additional 5-FU needling or other urgical procedure, wa analyzed by Kaplan-Meier urvival analyi, and rik factor for failure of the initial 5-FU needling reviion were analyzed by Cox proportional hazard regreion analyi. REULT: The cumulative ucce rate of the initial 5-FU needling reviion wa 45% at 1 year, 33% at 2 year, and 28% at 4 year. Failure of the initial 5-FU reviion correlated ignificantly with preneedling IOP > 30 mm Hg (P = .0003), lack of MMC ue during the previou filtration urgery (P = .013), and IOP >10 mm Hg immediately following needling reviion (P = .0012) according to Cox’ proportional hazard regreion analyi. CONCLUION: Pre-needling IOP > 30 mm Hg, lack of MMC ue during the previou filtration urgery, and IOP > 10 mm Hg immediately after needling were found to be ignificant rik factor for failure of the initial 5-FU needling procedure. Therefore, it i important to monitor IOP cloely following needling reviion in thoe patient with uch rik factor. They are more likely to require additional therapeutic intervention, including repeat needling reviion.