Retinoblatoma metatatic to the ovary in a patient with Waardenburg yndrome

PURPOE: To report a child with retinoblatoma and Waardenburg yndrome who developed ovarian metatae. DEIGN: Interventional cae report. METHOD: Unilateral retinoblatoma wa diagnoed in a 3-year-old girl with Waardenburg yndrome and leukocoria in the right eye. The patient had a Reee-Ellworth Group Va tumor and underwent enucleation. Two year later, he developed metatatic dieae involving the bone marrow, right humeru, both upraorbital bone, and both tibia. he wa treated with chemotherapy, orbital irradiation, and bone marrow tranplant but returned 7 month later with back pain and urinary retention. REULT: Exploratory laparotomy revealed a right ovarian ma, and the excied ovary howed metatatic retinoblatoma. The child underwent chemotherapy and remained aymptomatic for 9 month, when brain metatae were diagnoed. he died within 2 day of admiion. CONCLUION: We believe that thi i the firt decription of a patient with retinoblatoma and Waardenburg yndrome and of an ovarian metatai from retinoblatoma.