Abstract :
PURPOE: To examine the relationhip between baeline rik factor and utained decreae of viual field (DVF) and utained decreae of viual acuity (DVA).
DEIGN: Cohort tudy of participant in the Advanced Glaucoma Intervention tudy (AGI).
METHOD: Thi multicenter tudy enrolled patient between 1988 and 1992 and followed them until 2001; 789 eye of 591 patient with advanced glaucoma were randomly aigned to one of two urgical equence, argon laer trabeculoplaty (ALT)-trabeculectomy-trabeculectomy (ATT) or trabeculectomy-ALT-trabeculectomy (TAT). Thi report i baed on data from 747 eye. Eye were offered the next intervention in the equence upon failure of the previou intervention. Failure wa baed on recurrent intraocular preure elevation, viual field defect, and dik rim criteria. tudy viit occurred every 6 month; potential follow-up ranged from 8 to 13 year. For each intervention equence, Cox multiple regreion analye were ued to examine the baeline characteritic for aociation with two viion outcome: DVF and DVA. The magnitude of the aociation i meaured by the hazard ratio (HR), where HR for binary variable i the relative change in the hazard (or rik) of the outcome in eye with the factor divided by the hazard in eye without the factor, and HR for continuou variable i the relative change in the hazard (or rik) of the outcome in eye with a unit increae in the factor.
REULT: Characteritic aociated with increaed DVF rik in the ATT equence are: le baeline viual field defect (hazard ratio [HR] = 0.86, P < .001, 95% CI = 0.82–0.90), male gender (HR = 2.23, P < .001, 1.54–3.23), and wore baeline viual acuity (HR = 0.96, P = .001, 0.94–0.98); in the TAT equence: le baeline viual field defect (HR = 0.93, P = .001, 0.89–0.97) and diabete (HR = 1.87, P = .007, 1.18–2.97). Characteritic aociated with increaed DVA rik in both treatment equence are better baeline acuity (ATT: HR = 1.05, P < .001, 1.02–1.09; TAT: HR = 1.06, P < .001, 1.03–1.08), older age (ATT: HR = 1.05, P = .001, 1.02–1.08; TAT: HR = 1.04, P = .002, 1.01–1.06), and le formal education (ATT: HR = 1.92, P = .001, 1.29–2.88; TAT: HR = 1.77, P = .002, 1.22–2.54).
CONCLUION: For DVF, rik factor were better baeline viual field in both treatment equence, male gender, and wore baeline viual acuity in the ATT equence, and diabete in the TAT equence. For DVA, rik factor in both treatment equence were better baeline viual acuity, older age, and le formal education.
