A pectrum of clinical manifetation of gelatinou drop-like corneal dytrophy in japan

Purpoe Typical manifetation of gelatinou drop-like corneal dytrophy (GDLD) have been documented in pat tudie. In practice, however, we ee few typical cae and encounter many with atypical clinical manifetation. Moreover, there have been no detailed report about the variou clinical preentation. The purpoe of thi tudy i to decribe a clinical ubclaification for GDLD. Deign Obervational cae erie. Method A retropective, obervational cae erie tudy wa conducted at a ingle intitution, Oaka Univerity Hopital. Examined were 18 eye of ten patient with GDLD with no prior urgery. All were found to have M11 mutation. Uing lit-lamp examination we performed a phenotypic claification. Reult We claified GDLD patient into four group. They included band keratopathy type (even eye of four patient), tromal opacity type (five eye of three patient), kumquat-like type (four eye of two patient), and typical mulberry type (two eye of two patient). Concluion Gelatinou drop-like corneal dytrophy i thought to be the reult of mutation in M11; however, it ha variou clinical manifetation. To our knowledge, thi tudy i the firt to report the range of clinical phenotype of GDLD in a Japanee population. A mot clinician have no criteria for diagnoing GDLD, many cae are likely to be overlooked or be mitaken for other condition. We believe that our preent claification will be ueful for the diagnoi of GDLD.