Author/Authors :
G.R. Abecai، نويسنده , , B.M. Yahar، نويسنده , , Y. Zhao، نويسنده , , N.M. Ghiavand، نويسنده , , . Zarepari، نويسنده , , E.H. Branham، نويسنده , , A.C. Reddick، نويسنده , , E.H. Trager، نويسنده , , . Yohida، نويسنده , , J. Bahling، نويسنده , , E. Filippova، نويسنده , , . Elner، نويسنده , , M.W. Johnon، نويسنده , , A.K. Vine، نويسنده , , P.A. ieving، نويسنده , , .G. Jacobon، نويسنده , , J.E. Richard، نويسنده , , A. waroop، نويسنده ,
Abstract :
Age-related macular degeneration (AMD) lead to geographic atrophy (GA) and/or choroidal neovacularization (CNV). Coniderable data exit in upport of a genetic predipoition for AMD. Recent linkage tudie have provided evidence in favor of everal AMD uceptibility loci. The author performed a high-reolution (5-CM) genome can of 412 affected relative pair that were enriched for late-tage dieae (GA and/or CNV). Nonparametric linkage analyi wa performed uing two different diagnotic criteria, and alo by dividing the affected individual according to GA or CNV phenotype. The reult demontrate evidence of linkage in region that were uggeted in at leat one previou tudy at chromoome 1q (236 to 240 cM in the Marhfield genetic map), 5p (40 to 50 cM), and 9q (111 cM). Multipoint analyi of affected relative with CNV provided evidence of additional uceptibility loci on chromoome 2p (10 cM) and 22q (25 cM). A recently identified Gln5345 Arg change in HEMICENTIN-1 on chromoome 1q 25 wa not detected in 274 affected member in the retricted group with AMD, 346 additional patient with AMD, and 237 unaffected control. Thee reult conolidate the chromoomal location of everal AMD uceptibility loci and, together with previou report, hould facilitate the earch for dieae-aociated equence variant.—Han E. Groniklau
