Ocular axial length in homocytinuria patient with and without ocular change: Effect of early treatment and biochemical control. Mulvihill A, O’Keefe M, Yap , Naughten E, Howard P, Lanigan B. J AAPO 2004;8:254–258.

The author evaluated all patient with homocytinuria attending the Irih National Center for Inherited Metabolic Diorder to etablih whether myopia in homocytinuria could be attributable to increaed ocular axial length. Ocular axial length were meaured in a total of 27 patient (15 male and 12 female) with a mean age of 24.0 year (range, 11.8 to 36.3 year). Fourteen patient were detected by newborn creening while 13 were late detected. Eye with no ocular pathology (28 eye) had a mean pherical equivalent of −0.25 D and a mean axial length of 23.4 mm ± 0.9 mm. Eye with phacodonei or len ubluxation (12 eye), had a mean refractive error of −10.7 D and a mean axial length of 23.8 mm ± 1.9 mm. Eye with complete len dilocation (12 eye) were optically aphakic and had a mean refractive error of +12.9 D and a mean axial length of 24.9 mm ± 0.9 mm. All patient with normal eye had good long-term metabolic control while thoe with ocular abnormalitie did not. Eye with complete len dilocation had ignificantly longer mean axial length than normal eye (P = .0163). The author concluded that ocular axial length i ignificantly increaed in individual with homocytinuria and len dilocation. Increaed axial length i a complication that ha not been previouly decribed in homocytinuria and may be preventable with early treatment and good biochemical control.