Objective analyi of retinal damage in HIV-poitive patient in the HAART era uing OCT

Purpoe To ae retinal nerve fiber layer (RNFL) thickne in patient with human immunodeficiency viru (HIV) dieae without cytomegaloviru retiniti (CMV). Deign A cae-control tudy. Method The tudy included 113 eye of 65 patient in one center. Thickne of RNFL along a 3.4-mm-diameter circle centered on the optic nerve head wa evaluated uing third-generation optical coherence tomography. Patient in group A (39 eye of 22 patient) were human immunodeficiency viru-negative control ubject. Group B (36 eye of 18 patient) wa compoed of HIV patient with no hitory of CMV retiniti and CD4 count conitently above 100. Group C (38 eye of 25 patient) compried HIV patient with no hitory of CMV retiniti but a hitory of CD4 count le than 100 at ome point lating for at leat 6 month. Reult The average RNFL thicknee in group A, B, and C were 103.33 ± 8.50 μm, 103.30 ± 9.28 μm, and 90.10 ± 12.50 μm, repectively. Group C had ignificantly thinner overall RNFL than either of the group A and B (Tukey-Kramer). Thi difference wa mot prominent in temporal, uperior, and inferior retinal area. No difference wa in naal retinal area, nor between group A and B in any of the area. Concluion ignificant RNFL thinning occur in HIV patient without CMV retiniti and with low CD4 count compared with the ame ubgroup of patient with CD4 count increaed to above 100 and HIV-negative control ubject. Third-generation OCT may be ueful in diagnoi of early ubclinical HIV-aociated viual functional lo.