The afety profile of long-term, high-doe intraocular corticoteroid delivery

Purpoe To report the feaibility and afety profile of 2-mg and 6-mg fluocinolone acetonide implant after long-term follow-up in eye with choroidal neovacularization (CNV). Deign Propective, noncomparative, interventional cae erie of patient with non-age-related ubfoveal choroidal neovacularization enrolled in a compaionate ue protocol. Method utained drug delivery device containing either 2 mg (eight eye) or 6 mg (ix eye) of fluocinolone acetonide were implanted through the par plana into the vitreou cavity of 14 patient with predominantly claic, ubfoveal CNV. The main outcome meaure were complication related to the device. econdary outcome meaure were involution of etablihed CNV, inhibition of recurrent CNV, and viual acuity. Reult Patient had a diagnoi of ocular hitoplamoi (even), myopic degeneration (four), angioid treak (two), and punctate inner choroidopathy (one). Patient were followed for an average of 33 month (range, 16 to 40 month). All 14 eye developed elevated intraocular preure and cataract. Four eye developed nonichemic central retinal vein occluion. Complication required implant removal in 8 eye. Ten of 14 eye demontrated involution of CNV or inhibition of recurrent CNV. Ten eye had table or improved viual acuity. Median initial viual acuity wa 20/64. Median final viual acuity wa 20/40. Concluion Long-term follow-up demontrate a ignificant complication rate with the utained releae of high-doe intraocular corticoteroid. The complication are treatable, and eye can retain good viion. Thi therapeutic approach warrant further tudy to identify if lower doe of corticoteroid may reduce the complication rate yet till be effective in treating ocular dieae.