Peritent diabetic macular edema i aociated with elevated hemoglobin A1c

Purpoe To ae the correlation between peritent diabetic macular edema and hemoglobin A1c (HbA1C). Deign Retropective tudy. Method Record of type 2 diabetic patient who received eye care for peritent clinically ignificant macular edema (CME) from January 2002 to January 2004 were reviewed. ubject who met one of two criteria were identified: 1) peritent CME, detected by contact len biomicrocopy and fluorecein angiography, depite at leat two focal laer photocoagulation (FLP) performed at leat 3 month before the current diagnoi, or 2) a hitory of CME with reolution of macular edema at the time of examination. Patient alo needed to have had their HbA1C meaured at the John Hopkin Hopital within 3 month of meeting thee criteria. Reult The tudy identified 92 patient (152) eye with peritent CME and 32 patient (56 eye) with reolved CME. HbA1C value ranged from 5.3% to 15.6% (mean, 8.9%; median, 8.7%) and 5.3% to 9.7% (mean, 6.7%; median, 6.6%) among patient with peritent and reolved edema (P = .0005). Among the 32 patient with peritent unilateral CME, mean HbA1C wa 8.6% (median 8.5%), and among the 60 patient with bilateral CME, mean HbA1C wa 9.1% (median, 8.9%). Of patient with peritent CME, 74% had HbA1C greater than 7.5% compared with 12.5% of the patient with reolved CME (P = .0005). Concluion Peron with type 2 diabete and peritent CME have higher HbA1C at time of their dieae than patient with reolved CME. Patient with bilateral dieae have more elevated HbA1C than thoe with unilateral dieae.