Eye-banking rik factor for fungal endophthalmiti compared with bacterial endophthalmiti after corneal tranplantation

Purpoe To track the relative frequency and explore poible rik factor of fungal compared with bacterial endophthalmiti after corneal tranplantation. Deign Cae-comparion tudy neted in a urveillance regitry. Method We examined, among recipient who underwent urgery from January 1991 through December 2003, demographic and eye-banking characteritic of potkeratoplaty endophthalmiti cae that were reported to the Eye Bank Aociation of America by U eye bank. Potential predictor of fungal compared with bacterial endophthalmiti were examined uing multiple logitic regreion. Reult Of 234 reported cae of potkeratoplaty endophthalmiti reported by U eye bank, 46 cae (19.7%) were fungal, and 130 cae (55.6%) were bacterial. Concordant culture of the reidual donor corneocleral rim or preervation medium occurred ignificantly more often with fungal than bacterial endophthalmiti (P = .009). After the introduction of Optiol-G, the odd of bacterial relative to fungal endophthalmiti decreaed by 77% (95% confidence interval, 44% - 91%). After adjutment for the preervation method and other eye-banking variable, the odd of fungal endophthalmiti wa 3.4 (95% confidence interval, 1.6 - 7.4) time that of bacterial endophthalmiti, when donor corneal preervation wa 4 day or longer. Concluion The frequency of potkeratoplaty bacterial endophthalmiti compared with fungal endophthalmiti fell after widepread ue of a corneal preervation medium upplemented with gentamicin and treptomycin. Further improvement in corneal preervation procedure are needed.