Abstract :
Purpoe
To review the relation of optic neuriti to multiple cleroi (M) and the indication, modalitie, and reult of therapy for optic neuriti, for both viual and general neurologic function.
Deign
Literature review and author’ experience.
Method
Analyi of both laboratory and clinical evidence upporting the ue of corticoteroid, immunomodulation agent, and other modalitie in the treatment of optic neuriti and M.
Reult
Although treatment of optic neuriti with corticoteroid may haten viual recovery to a minor degree, it ha no long-term beneficial effect on viual outcome. Optic neuriti i frequently the initial manifetation of multiple cleroi. The rik of later development of clinically definite M (CDM) correlate with white matter demyelinative leion on magnetic reonance imaging (MRI). The role of corticoteroid therapy alone in reducing the rik of ubequent M i unclear, but recent tudie ugget that the combination of immunomodulation agent (IMA) and corticoteroid ignificantly reduce the later development of M. Current reearch indicate that, contrary to previou doctrine, axonal damage i an early finding in M.
Concluion
The rik of M after optic neuriti may be predicted. The ue of corticoteroid and IMA, particularly in thoe at ubtantial rik, reduce the frequency and everity of developing CDM. Earlier, more aggreive therapy in optic neuriti may be proven to reduce permanent axonal injury and progreive diability in M.
