Regional Pattern of ight-Threatening Diabetic Macular Edema

Purpoe To define regional pattern of macular thickening in diabetic macular edema (DME). Deign Retropective cae erie. Method etting: Retina practice. patient population: Fifty-two normal eye of 48 patient and 100 eye of 80 patient with DME. experimental procedure: We meaured retinal thickne for nine zone and total macular volume uing the 3.5-mm diplay of an optical coherence tomograph (OCT). We determined the normal range of value for zone, and then normal range of value for the difference in thickne between each pair of zone, termed comparion. main outcome meaure: Frequencie of increaed zonal thickne, increaed total macular volume, and abnormalitie in zonal comparion. Reult We found the following abnormalitie: increaed total macular volume 49% (49/100), increaed foveal zone thickne 46% (46/100), increaed inner parafoveal zone thickne (average 42.2% for the four zone), and increaed outer zone thickne (average 34.3% for the four zone). Abnormal two-zone comparion were found in 1027 of the 7200 poible comparion (14.3%). Of thee abnormal comparion, the fovea wa thicker relative to another zone in 26%; the four inner parafoveal zone were thicker relative to other zone in 8.7% to 15.2% (average 13.0%); and the four outer zone were thicker relative to other zone in 3.9% to 7.6% (average 6%). Eighty-eight percent (88/100) of the eye choen on clinical ground a needing focal laer photocoagulation were detected. Concluion A broader concept of OCT abnormality, which include abnormalitie in zonal relationhip, may improve automated detection of DME compared with clinical judgment.