Genome-wide can for Myopia in the Old Order Amih

Purpoe To identify myopia uceptibility gene influencing common myopia in 34 Old Order Amih familie, a genetically well-defined founder population. Deign A propective tudy of familie with myopia coniting of a minimum of two individual affected with myopia. Method Extended familie coniting of at leat two ibling affected with myopia were acertained. A genome-wide linkage can uing 387 marker wa conducted by the Center for Inherited Dieae Reearch (CIDR). Linkage analye were conducted with parametric (autoomal dominant, fixed penetrance model) and nonparametric method. Model-free linkage analyi wa alo performed maximizing over penetrance and over dominance (that i, fitting a wide range of both dominant and receive model). Reult Under the fixed penetrance model, the maximum two-point heterogeneity LOD core (HLOD) wa 1.59 at D20451 and the maximum multipoint HLOD wa 1.92 at D61021. The nonparametric maximum multipoint (NPL) at D32427 had a P-value of .0005. Under the model-free analyi, multipoint heterogeneity LOD core of 2.03 were oberved on both chromoome 8 (under a receive model between D81130 and D81106) and X (under a receive model between DX6800 and DX6789). Reanalye of chromoome 3, 6, 8, 20, and X uing the bet penetrance model reulted in maximum multipoint HLOD of 1.84 at D33053; 1.84 at D32427; 2.04 at D81130; and 2.34 at DX6800. Concluion The locu on chromoome 8p23 independently confirm a report by Hammond and aociate mapping a myopia quantitative trait loci (QTL) to thi region.