Rik Factor for Progreion to Penetrating Keratoplaty in Patient With Keratoconu

Purpoe To determine clinical and demographic rik factor for corneal tranplantation in keratoconu patient. Deign Cae control tudy. Method etting: Tertiary referral center. tudy population: All keratoconic eye preenting to the Duke Univerity Eye Center from January 1, 1997, to December 31, 2002. obervation procedure and outcome meaure: Cae were defined a eye undergoing tranplantation during the tudy period for keratoconu. Control were defined a eye that did not undergo tranplantation. Cae were compared with control to determine clinical and demographic rik factor for corneal tranplantation. Reult A total of 131 eye with keratoconu were tudied; 59 cae were compared with 72 control. Group were imilar with repect to ex and race. ignificant univariate rik factor for corneal tranplantation were bet-corrected viion wore than 20/40 (OR 3.2, 95% CI 1.1 to 9.8), cylinder >10.0 diopter (OR 3.5, 95% CI 1.0 to 12.4), and average keratometry >55 diopter (OR 5.6, 95% CI 1.4 to 21.9). In multivariate analyi, age 30 or younger conferred a evenfold increaed rik of tranplantation compared with age of more than 40 (OR 7.7 for age 21 to 30 and OR 25.8 for age ≤20). Multivariate analyi alo howed duration of dieae 5 year or le and teep average keratometry a ignificant rik factor. Concluion A ubet of young keratoconic patient with high keratometry value may repreent an underrecognized rik group for corneal tranplantation. Bet-corrected viual acuity wore than 20/40 at preentation and atigmatim are other clinical indicator of increaed rik of corneal tranplantation in keratoconu patient.