Prophylactic Laer Treatment Haten Choroidal Neovacularization in Unilateral Age-Related Maculopathy: Final Reult of the Druen Laer tudy

Purpoe The Druen Laer tudy evaluated macular laer to prevent choroidal neovacularization (CNV) and viion lo in high-rik age-related maculopathy (ARM). Deign Propective, interventional, randomized, controlled clinical trial in five hopital center. Method Patient in the unilateral group had neovacular ARM and druen in the tudy eye. tudy eye were randomized to laer-treated or no-laer group. For patient in the bilateral druen group, eye were randomized to right eye, laer or no laer; and left eye, alternative. Laer treatment compried 12 argon pot. Outcome wa bet-corrected viual acuity and CNV ign, which were monitored for 3 year. Reult In the unilateral group, viion lo occurred in 21 (28.8%) of 73 patient in laer v 13 (19.7%) of 66 no-laer patient (P = .214). Incidence of CNV wa 27 (29.7%) of 91 in laer v 15 (17.65%) of 85 no-laer patient (P = .061). CNV onet wa approximately 6 month earlier in laer-treated compared with no-laer patient (P = .05). In the bilateral group, viion lo occurred in ix (8.3%) of 72 laer-treated v 10 (13.9%) of 72 fellow eye (P = .3877). CNV incidence wa 12 (11.6%) of 103 in laer-treated v even (6.8%) of 103 fellow eye (P = .225). There wa no difference in onet of CNV. Concluion Reult do not upport prophylactic laer of the fellow eye of patient with neovacular ARM. It role in patient with bilateral druen remain unclear.