Correlation Between Retinal Nerve Fiber Layer Thickne and Central Corneal Thickne in Patient With Ocular Hypertenion: An Optical Coherence Tomography tudy Original Reearch Article

Purpoe To correlate the retinal nerve fiber layer (RNFL) thickne and optic nerve head (ONH) parameter meaured by optical coherence tomography (OCT) with central corneal thickne (CCT) meaurement in patient with ocular hypertenion (OHT). Deign Obervational cro-ectional tudy. Method etting: Tertiary care referral teaching intitute. tudy population: Fifty-one eye of 51 patient with OHT and 35 eye of 35 normal ubject. Both group were tratified into thin (CCT ≤555 μm) and thick (CCT >555 μm) cornea ubet. Ocular hypertenive were further tratified by CCT into ≤555 μm, 556 to 588 μm, and >588 μm ubet. obervation procedure: RNFL thickne (average, uperior average, and inferior average) and ONH parameter were meaured by OCT. CCT wa meaured by ultraonic pachymetry. main outcome meaure: Correlation between CCT and OCT meaurement of RNFL and ONH parameter. Reult In the OHT group, CCT correlated ignificantly with all three RNFL meaurement (Pearon’ coefficient r = 0.412, 0.484, and 0.380, repectively) but with only four ONH parameter (cup-to-dik area ratio, cup area, rim area, and horizontally integrated rim width; r = −0.459, −0.283, 0.421, and 0.436, repectively). The RNFL in ocular hypertenive with CCT ≤555 μm wa ignificantly thinner than in thoe with thick cornea (analyi of variance, pot hoc Bonferroni comparion, P < .001). RNFL thickne of normal ubject and ocular hypertenive with CCT >555 μm were imilar. Concluion Ocular hypertenive with CCT ≤555 μm may repreent patient who have either very early undetected glaucoma or an inherent tructural predipoition to glaucomatou damage. Thi may in part explain the higher rik of thee patient for progreion to glaucoma.