Aociation of Blood Preure tatu With the Optic Dik tructure in Non-glaucoma ubject: The Thealoniki Eye tudy Original Reearch Article

Purpoe To tudy the aociation of blood preure (BP) tatu on the optic dik tructure a meaured with the Heidelberg Retina Tomograph (HRT) in people without glaucoma. Deign Cro-ectional population-baed etting tudy. Method Conecutive participant in the Thealoniki Eye tudy were included in thi tudy. HRT image of the optic dik and BP meaurement were taken. Hypertenion wa defined a a ytolic BP (BP) ≥140 mm Hg, diatolic BP (DBP) ≥90 mm Hg, or both. ubject were claified in three group by BP and DBP. The Krukal-Walli tet wa ued to compare the three group with repect to the HRT parameter. Regreion model adjuted for age, gender, height, dik ize, intraocular preure, cardiovacular dieae, diabete, and duration of antihypertenive treatment were ued for each HRT parameter to compare value among the different group. The P value wa conidered ignificant at <.05. Reult A total of 232 ubject were included in the analyi. Rim area wa ignificantly different among group when DBP wa conidered a the criterion to claify ubject (P = .005). In regreion model, cup area, and cup-to-dik (c/d) ratio were increaed in ubject with normal DBP that wa the reult of treatment, a compared with both the high DBP and untreated normal DBP group. Concluion In patient without glaucoma, the DBP <90 mm Hg that reult from antihypertenive treatment i aociated with increaed cupping and decreaed rim area of the optic dik. Thi information hould be conidered in reearch aiming to define the role of the BP tatu a an independent factor initiating optic dik change and/or a a contributing factor to glaucoma damage.