Ultra-high Reolution Optical Coherence Tomography Aement of Photoreceptor in Retiniti Pigmentoa and Related Dieae

Purpoe To ae photoreceptor integrity in patient with retiniti pigmentoa (RP) and related dieae uing ultra-high reolution optical coherence tomography (UHR-OCT) and to correlate foveal photoreceptor lo with viual acuity. Deign Obervational cae erie. Method Nine eye of nine patient with RP and related dieae were imaged with UHR-OCT at the ophthalmology clinic. Patient were diagnoed baed on hitory, examination, fluorecein angiography, and electroretinography. Concurrently, 36 eye of 36 normal ubject were imaged with UHR-OCT. Central foveal thickne (CFT) and foveal outer egment/pigment epithelium thickne (FOPET) were defined and meaured on UHR-OCT image in all ubject and were compared between the two group uing unpaired t tet. The two thickne meaurement in RP patient were correlated with viual acuity uing Pearon correlation and linear regreion. Reult UHR-OCT demontrated macular photoreceptor thinning in all RP patient. The difference in CFT between RP patient and normal ubject wa not tatitically ignificant (P = .103), but the difference in FOPET between the two group wa ignificant (P = .003). Viual acuity howed a fair correlation with CFT (Pearon r = −0.43, r2 = 0.187, P = .245) and an excellent correlation with FOPET (Pearon r = −0.942, r2 = 0.887, P < .0001). Concluion In the current tudy uing UHR-OCT, a new thickne meaurement termed FOPET i demontrated to quantify photoreceptor lo. FOPET wa tatitically thinner in patient with RP and related dieae than in normal eye and howed correlation with logMAR viual acuity. FOPET appear to be a probable predictor of viual acuity in RP.