canning Laer Polarimetry With Variable and Enhanced Corneal Compenation in Normal and Glaucomatou Eye Original Reearch Article

Purpoe To invetigate whether correction for atypical birefringence pattern (ABP) uing canning laer polarimetry with enhanced corneal compenation (LP-ECC) reduce the everity of ABP compared with variable corneal compenation (LP-VCC) and improve the correlation with viual function. Deign Propective obervational tudy. Method Normal and glaucomatou eye enrolled from four clinical ite underwent complete examination, automated perimetry, LP-ECC, and LP-VCC. Eye were characterized in three group baed upon the typical can core (T): normal birefringence pattern (NBP) wa defined a T ≥ 80, mild ABP a T 61 to 79, and moderate-evere ABP a T ≤ 60. For each of four LP parameter, the area under the ROC curve (AUROC) wa calculated to compare the ability of LP-ECC and LP-VCC to dicriminate between normal and glaucomatou eye. Reult Eighty-four normal volunteer and 45 glaucoma patient were enrolled. Mean T wa ignificantly (P < .001) greater uing LP-ECC (98.0 ± 6.6) compared with LP-VCC (83.4 ± 22.5). The frequency of moderate-evere ABP image wa ignificantly (P < .001, McNemar tet) higher uing LP-VCC (18 of 129, 14%) compared with LP-ECC (one of 129, 0.8%). Two LP-ECC parameter (temporal uperior naal inferior temporal [TNIT] average and inferior average) had ignificantly (P = .01, P < .001) higher correlation (r = .45, r = .50, repectively) with MD compared with LP-VCC (r = .34, r = .37). Among eye with moderate-evere ABP (n = 18), inferior average obtained uing LP-ECC had ignificantly (P = .03) greater AUROC (0.91 ± 0.07) compared with LP-VCC (0.78 ± 0.11). Concluion LP-ECC ignificantly reduce the frequency and everity of ABP compared with LP-VCC and improve the correlation between RNFL meaure and viual function.