The Effect of evoflurane and Ketamine on Intraocular Preure in Children During Examination Under Anetheia Original Reearch Article

Purpoe We tudied the effect on intraocular preure (IOP) of anetheia adminitered during examination under anetheia (EUA) in children. Deign Randomized clinical trial. Method Thi randomized trial compared IOP after inhaled evoflurane ga to that after intramucular ketamine hydrochloride in children undergoing EUA. IOP wa meaured in 30 eye with TonoPen XL (Mentor, Inc, Norwell, Maachuett, UA) a oon a poible after anetheia induction (T1) and two, four, ix, and eight minute thereafter. At the ame time, we recorded ytolic and diatolic blood preure (BP, DBP) and heart rate (HR). Reult Compared with the mean IOP at T1, IOP in the evoflurane group wa ignificantly lower for all meaurement from two to eight minute thereafter (mean decreae in IOP: two minute = 12%, four minute = 19%; ix minute = 19%; eight minute = 17%, all P ≤ .01). In the ketamine group, mean IOP wa not ignificantly changed from T1 through ix minute, wherea at eight minute, it wa 7% lower (P = .03). BP and DBP were ignificantly lower for evoflurane than for ketamine at all meaurement from two minute onward, and HR wa lower for evoflurane than for ketamine at two, four, and ix minute. Concluion IOP meaured after ketamine edation i more likely to repreent the awake IOP than that after evoflurane anetheia. Change in BP, DBP, and HR caued by evoflurane ugget that hemodynamic alteration may underlie it effect on IOP.