Prorenin Level in Retinopathy of Prematurity

Purpoe To evaluate erum prorenin level in preterm infant with or without retinopathy of prematurity (ROP). Deign Noncomparative retropective cae control tudy. Method erum prorenin level in children with a getational age younger than 36 week were meaured with antibody-activating direct enzyme kinetic aay. Reult The mean prorenin concentration were higher in preterm infant with ROP than in infant without ROP at every time point: from 26 to 30 week, 2326 ± 334 μg/ml (mean ± E [tandard error]) (n = 3) and 1164 ± 234 μg/ml (n = 3), repectively (P < .05); from 31 to 35 week, 1760 ± 496 μg/ml (n = 10) and 957.1 ± 139 μg/ml (n = 25) (P < .05); from 36 to 40 week, 958.2 ± 194.2 μg/ml (n = 23) and 470.1 ± 32.6 μg/ml (n = 67) (P < .01); and from 41 to 45 week, 575.8 ± 148.4 (n = 9) and 385.6 ± 47.9 (n = 13), which i not ignificantly different. Concluion Prorenin level in preterm infant can predict which infant will develop ROP.