Profile of Obeity, Weight Gain, and Quality of Life in Idiopathic Intracranial Hypertenion (Peudotumor Cerebri) Original Reearch Article

Purpoe Obeity and weight gain are known rik factor for idiopathic intracranial hypertenion (IIH; or peudotumor cerebri). The author examined profile of body ma index (BMI) and pattern of weight gain aociated with IIH. They alo examined viion-pecific health-related quality of life (HRQOL) in newly diagnoed IIH patient and explored the relative contribution of obeity and weight gain to overall HRQOL in thi diorder. Deign Matched cae-control tudy. Method Female patient with newly diagnoed IIH (n = 34) and other neuro-ophthalmologic diorder (n = 41) were enrolled in a cae-control tudy to ae pattern of elf-reported weight gain. The HRQOL wa examined uing the 25-Item National Eye Intitute Viual Function Quetionnaire (NEI-VFQ-25) and the F-36 Health urvey (Phyical Component ummary and Mental Component ummary [MC]). Reult Higher BMI were aociated with greater rik of IIH (P = .003, logitic regreion analyi adjuting for cae–control matching), a were higher percentage of weight gain during the year before ymptom onet (P = .004). Moderate weight gain (5% to 15%) wa aociated with a greater rik of IIH among both obee and nonobee patient. Obeity and weight gain influenced the relation between HRQOL and IIH only for ubcale core reflecting mental health (F-36 MC). The NEI-VFQ-25 and F-36 ubcale core were lower in IIH compared with other neuro-ophthalmologic diorder and publihed norm. Concluion Higher level of weight gain and BMI are aociated with greater rik of IIH. Even nonobee patient (BMI <30) are at greater rik for IIH in the etting of moderate weight gain. Viion-pecific and overall HRQOL are affected to a greater extent in IIH than in other neuro-ophthalmologic diorder.