Viual Performance Uing a Retinal Prothei in Three ubject With Retiniti Pigmentoa Original Reearch Article

Purpoe To ae viual tak performance in three blind ubject implanted with epiretinal prothee. Deign Propective, invetigational device exemption trial. Method Three ubject with light perception or no light perception viion were enrolled at a ingle center. All ubject had retiniti pigmentoa (RP). Main incluion criteria: light perception or wore viion in one eye and ome viual experience a an adult before blindne. Main excluion criteria included other ophthalmic problem. A prototype retinal prothei wa implanted in the eye with wore light enitivity. The prothei had 4 × 4 array of platinum electrode tacked to the epiretinal urface. The prothei wa wirelely controlled by a computer or by a head-worn video camera. Viual function teting wa performed in ingle maked or double maked fahion. core from the viual tak were compared to chance to determine tatitical ignificance. Reult The ubject performed ignificantly better than chance in 83% of the tet. Uing the video camera, ubject cored a follow on imple viual tak: locate and count object (77% to 100%), differentiate three object (63% to 73%), determine the orientation of a capital L (50% to 77%), and differentiate four direction of a moving object (40% to 90%). A ubet of tet compared camera etting uing multipixel v ingle pixel. Uing multipixel etting, ubject performed better (17%) or equivalent (83%) in accuracy and better (25%) or equivalent (75%) in reaction time. Concluion Three RP implant ubject ued epiretinal prothee to perform imple viual tak. Multipixel etting proved lightly more effective than ingle pixel etting.