Treatment of Bilateral Refractive Amblyopia in Children Three to Le Than 10 Year of Age Original Reearch Article

Purpoe To determine the amount and time coure of binocular viual acuity improvement during treatment of bilateral refractive amblyopia in children three to le than 10 year of age. Deign Propective, multicenter, noncomparative intervention. Method One hundred and thirteen children (mean age, 5.1 year) with previouly untreated bilateral refractive amblyopia were enrolled at 27 community- and univerity-baed ite and were provided with optimal pectacle correction. Bilateral refractive amblyopia wa defined a 20/40 to 20/400 bet-corrected binocular viual acuity in the preence of 4.00 diopter (D) or more of hypermetropia by pherical equivalent, 2.00 D or more of atigmatim, or both in each eye. Bet-corrected binocular and monocular viual acuitie were meaured at baeline and at five, 13, 26, and 52 week. The primary tudy outcome wa binocular acuity at one year. Reult Mean binocular viual acuity improved from 0.50 logarithm of the minimum angle of reolution (logMAR) unit (20/63) at baeline to 0.11 logMAR unit (20/25) at one year (mean improvement, 3.9 line; 95% confidence interval [CI], 3.5 to 4.2). Mean improvement at one year for the 84 children with baeline binocular acuity of 20/40 to 20/80 wa 3.4 line (95% CI, 3.2 to 3.7) and for the 16 children with baeline binocular acuity of 20/100 to 20/320 wa 6.3 line (95% CI, 5.1 to 7.5). The cumulative probability of binocular viual acuity of 20/25 or better wa 21% at five week, 46% at 13 week, 59% at 26 week, and 74% at 52 week. Concluion Treatment of bilateral refractive amblyopia with pectacle correction improve binocular viual acuity in children three to le than 10 year of age, with mot improving to 20/25 or better within one year.