Optical Coherence Tomography Identification of Occult Choroidal Neovacularization in Age-related Macular Degeneration Original Reearch Article

Purpoe To evaluate and decribe the variou optical coherence tomography (OCT) feature of occult choroidal neovacularization (CNV) in age-related macular degeneration (AMD) at the time of diagnoi. Deign Propective, conecutive, obervational cae erie. Method One hundred and fifty-three eye of 130 conecutive patient with ubfoveal occult CNV diagnoed on canning laer ophthalmocope (LO) fluorecein angiography (FA) and LO indocyanine green angiography (ICGA) were evaluated with OCT. The diagnotic criteria for occult CNV on angiography were heterogeneou hyperfluorecence with late leakage in the macular region aociated with pigment epithelial detachment (PED), tippled hyperfluorecent dot, and ign of deterioration. OCT finding were evaluated and decribed. Reult A PED wa oberved on OCT in 98% (150 eye) either a a limited retinal pigment epithelium (RPE) elevation (54 eye [35.3%]) or a complete detachment (96 eye [62.7%]). Occult CNV correponded to zone of hyperreflectivity in contact with the RPE band and wa detected in 62.7% of eye. In fibrovacular PED (63 eye [65.5%]), the elevated RPE wa highlighted poteriorly by a moderately reflective band overlying a hyporeflective cavity. In erou PED, the cavity remained optically empty. The RPE in the detached zone howed change uch a fragmentation (137 eye [89.5%]). OCT alo howed intraretinal (122 eye [79.7%]) and ubretinal (64 eye [41.8%]) fluid. Concluion Analyi of the variou OCT feature oberved in thi tudy confirm the polymorphic nature of occult CNV in AMD, their exudative reaction, the almot contant preence of PED, and the different change in the RPE band. OCT examination, therefore, provide valuable data to confirm the feature of ubepithelial occult CNV.