Poterior Vitreomacular Adheion: A Potential Rik Factor for Exudative Age-related Macular Degeneration? Original Reearch Article

Purpoe To compare the tate of the poterior vitreou in exudative age-related macular degeneration (AMD) with eye with nonexudative AMD and control. Deign Propective, obervational cae erie. Method B-can ultraonography and optical coherence tomography (OCT) were performed in 163 eye from 82 ubject older than 55 year, 50 eye with exudative AMD, 57 with nonexudative AMD, and 56 control eye. Main outcome meaure were the number of eye with complete poterior vitreou detachment (PVD) by ultraound and the number of eye with central vitreomacular adheion by OCT. Reult By ultraonography, 17 (34.0%) of 50 eye with exudative AMD had PVD a compared with 41 (71.9%) of 57 eye with nonexudative AMD (P = .00002) and 34 (60.7%) of 56 control (P = .017). OCT detected peritent central vitreoretinal adheion urrounded by a detached poterior vitreou cortex in 18 (36%) of 50 eye with exudative AMD, ignificantly higher than in nonexudative AMD (4/57 [7%]; P < .0001) and in control (6/56 [10%]; P = .002). Concluion Peritent attachment of the poterior vitreou cortex to the macula may be another rik factor for the development of exudative AMD via vitreoretinal traction inducing chronic low-grade inflammation, by maintaining macular expoure to cytokine or free radical in the vitreou gel, or by interfering in tranvitreou oxygenation and nutrition of the macula. Inducing PVD may provide prophylactic benefit againt exudative AMD.