Triple Therapy of Vitrectomy, Intravitreal Triamcinolone, and Macular Laer Photocoagulation for Intractable Diabetic Macular Edema

Purpoe To evaluate the effect of a equentially combined triple therapy on intractable diabetic macular edema (DME). Deign Propective, interventional cae erie. Method Twenty-four eye from 24 ubject, diagnoed with intractable DME of nontractional origin, were ubjected to vitrectomy. Intravitreal triamcinolone acetonide injection and macular laer photocoagulation were conducted equentially at one and 14 day after vitrectomy. Bet-corrected viual acuity (BCVA) and central macular thickne (CMT) were recorded before urgery and at three, ix, and 12 month after triple therapy. Reult The mean (± tandard deviation [D]) logarithm of the minimum angle of reolution BCVA before and three, ix, and 12 month after the triple therapy were 0.88 ± 0.37, 0.55 ± 0.33, 0.56 ± 0.27, and 0.48 ± 0.28, repectively. The mean (± D) CMT before and three, ix, and 12 month after the triple therapy were 514 ± 187 μm, 253 ± 138 μm, 219 ± 95 μm, and 197 ± 91 μm, repectively. The change in both BCVA and CMT at three, ix, and 12 month from baeline were tatitically ignificant (P < .003). The major advere event after triple therapy were development of nuclear clerotic cataract (eight among 12 phakic eye) and elevation of intraocular preure (eight among 24 eye). Concluion The triple therapy may facilitate early recovery of viion and may improve the long-term outcome in ome patient with DME refractory to conventional monotherapy.