Characteritic of Untreated AID-related Cytomegaloviru Retiniti. I. Finding before the Era of Highly Active Antiretroviral Therapy (1988 to 1994) Original Reearch Article

Purpoe To identify factor related to variation in the appearance of untreated AID-related cytomegaloviru (CMV) retiniti in everely immunodeficient individual before the availability of highly active antiretroviral therapy (HAART) and to draw inference regarding early event in the natural hitory of CMV retiniti baed on clinical finding. Deign Retropective, obervational cae erie. Method We evaluated a erie of 100 adult patient with AID and newly diagnoed CMV retiniti before the HAART era who were not being treated with pecific anti-CMV therapy. Demographic factor, ophthalmic finding, and the influence of drug therapy (zidovudine, acyclovir) on leion characteritic were evaluated. Leion border opacity wa cored uing a four-point cale of everity. Reult Leion could be categorized by type (fulminant/edematou or indolent/granular) in only 66% of eye. evere leion border opacity (4+) wa related to preence of zone 1 leion (P = .032) and greater extent of dieae (P = .004). Acyclovir ue wa aociated with le evere opacity (P = .029) and le zone 1 involvement (P = .016). Early leion were adjacent to veel in 73% of eye; the fovea wa involved in 13% of eye. Concluion Leion location and drug ue that affect viru activity may influence the everity of leion border opacity, a meaure that may be more ueful than leion type in future clinical tudie of CMV retiniti. In contrat to earlier concept, CMV retiniti doe not eem to be a fovea-paring dieae. Finding in thi tudy can erve a a reference for invetigation into poible change in CMV retiniti ince the introduction of HAART.