Doe In Vitro uceptibility Predict Clinical Outcome in Bacterial Keratiti? Original Reearch Article

Purpoe To determine whether clinical outcome in bacterial keratiti are aociated with antibiotic uceptibility. Deign Retropective, ancillary tudy uing data and ample from a completed randomized clinical trial. Method Forty-two patient were enrolled with culture-confirmed bacterial keratiti at Aravind Eye Hopital in outh India. All patient received topical moxifloxacin and were randomized to receive either topical predniolone phophate or placebo. Outcome included time to epithelialization, bet pectacle-corrected viual acuity (BCVA), and infiltrate/car ize at three month. Bacterial iolate were cultured, and minimum inhibitory concentration (MIC) to moxifloxacin wa meaured uing Etet. Multiple linear regreion wa ued to ae the effect of MIC on outcome, adjuting for enrollment characteritic. Reult MIC wa aociated with three-month infiltrate/car ize: each two-fold increae in MIC wa aociated with a 0.33-mm average diameter increae in car ize (P = .01). MIC wa not aociated with three-month BCVA (P = .71) or time to epithelialization (P = .35). Concluion MIC wa aociated with infiltrate/car ize in bacterial keratiti. An ongoing larger, multicenter trial hould provide further information on whether thi aociation i maintained acro ubgroup of organim.