Evolution of Retinal Detachment in Poterior Retinopathy of Prematurity: Impact on Treatment Approach Original Reearch Article

Purpoe To provide inight into the coure of retinal detachment in eye with aggreive poterior retinopathy of prematurity (APROP). Deign Propective, multicenter, maked clinical trial. Method Multicenter trial baed on erial digital photographic imaging detailing five infant (in the Photographic creening for Retinopathy of Prematurity [PHOTO-ROP] tudy) in whom bilateral retinal detachment developed during the coure of the tudy. Reult Retinal detachment developed in both eye (n = 10) of all five infant depite peripheral retinal laer ablation. The mean birth weight wa 651.4 ± 45.30 g (range, 601 to 718 g), and the mean getation wa 26.75 ± 0.96 week (range, 24 to 26 week). APROP (flat neovacularization) wa preent in all eye at the time of treatment. Laer treatment wa performed at a mean potconceptual age of 37.25 ± 1.8 week (range, 35 to 39.57 week). Plu dieae reolved initially and then recurred (mean, 9.5 day) with progreion to retinal detachment; the mean potconceptual age at the time of retinal detachment wa 41.42 ± 3.6 week (range, 36 to 47.29 week). Untreated avacular retina became viible with regreion of flat preretinal neovacularization. All 10 eye howed preretinal vitreou organization (mot prominent naally) along the retinal urface without ignificant tranvitreal component. Concluion Eye with APROP may follow an atypical coure after laer ablation. uch eye may till fare poorly, even when plu dieae wane. Additional laer to avacular retina may be neceary after the overlying flat tage 3 neovacularization regree. The abence of obviou fibroi at the time of laer hould provide no reaurance a to reduced probability of progreion to retinal detachment.