The Variation in Optical Coherence Tomography–Meaured Macular Thickne in Diabetic Eye Without Clinical Macular Edema Original Reearch Article

Purpoe To determine the variation in optical coherence tomography (OCT)–meaured macular thickne in diabetic eye without clinical edema and to invetigate factor that might influence variation in macular thickne. Deign Retropective, obervational cae erie from a clinical practice. Method Review of clinical chart and longitudinal OCT meaurement of a conecutive erie of 56 eye of 56 patient with diabete but no clinical macular edema. Meaured variable include OCT central ubfield mean thickne (CMT), total macular volume (TMV), and logarithm of the minimum angle of reolution (logMAR) viual acuity. Reult Over a median follow-up of 17 month, interquartile range (IQR) (9, 23), the median variation in CMT wa 18 micron, IQR (11, 31), and the median variation in TMV wa 0.09 mm3, IQR (0.06, 0.16). Variation in CMT did not change ignificantly with increaing CMT. Abolute, but not relative, variation in TMV increaed with increaing baeline value (P = .0127 and P = .1538 for abolute variation and relative variation in TMV, repectively). The variation in CMT and TMV did not vary with follow-up time and did not vary with age, gender, race, hypertenion tatu, glycoylated hemoglobin, or retinopathy level. Concluion Variation in CMT and TMV in diabetic eye without DME over interval up to 17 month i no greater than OCT meaurement variability in eye without and with DME. A change in the OCT-meaured macular thickne greater than 10% of the baeline thickne i likely to repreent a true change in the macular thickne and not OCT meaurement variability, diurnal variation, or variability occurring over longer time cale.