The Need for tandardization of Antiretinal Antibody Detection and Meaurement Original Reearch Article

Purpoe To review the current literature on the detection and meaurement of antiretinal antibodie. Deign Collaborative eay. Method Literature review and interpretation. Reult There i trong evidence to ugget a role for antiretinal antibodie, particularly thoe targeting recoverin and α-enolae, in the pathogenei of autoimmune retinopathy (AIR). Additionally, numerou other autoantibodie have been decribed a putative mediator of retinal degeneration and more remain to be dicovered. However, aay method decribed in the literature by many laboratorie for the detection of circulating antiretinal antibodie have been varied and divere, making it difficult to interpret and compare their reult. Concluion There i currently little tandardization of laboratory method ued to detect and monitor antiretinal antibodie. To meaure and monitor level of circulating antiretinal antibodie optimally in patient with AIR, development of tandardized aay with tringent internal control i required. A multicenter collaborative and validation effort i encouraged to reach a conenu on thi iue.