hort-term Intraocular Preure Change Immediately After Intravitreal Injection of Anti–Vacular Endothelial Growth Factor Agent Original Reearch Article

Purpoe To ae hort-term trend and the need to monitor intraocular preure (IOP) change immediately after intravitreal injection of ranibizumab, bevacizumab, pegaptanib, and triamcinolone acetonide. Deign Retropective, interventional cae erie. Method Chart of 213 conecutive injection to 120 eye of 112 patient were reviewed. Preure were meaured before injection, immediately after injection (T0), and at five-minute interval until IOP wa le than 30 mm Hg. Optic nerve perfuion wa aeed by teting for hand movement viion and by indirect ophthalmocopic examination. Kaplan-Meier and Chi-quare analye of IOP after injection and correlation of IOP pike to drug, needle bore ize, injection volume, and hitory of glaucoma were performed. Reult Mean preinjection IOP wa 14 mm Hg (range, 7 to 22 mm Hg). Mean IOP at T0 wa 44 mm Hg (range, 4 to 87 mm Hg). All but one eye had at leat hand movement viion and a perfued optic nerve at T0. IOP wa reduced to le than 30 mm Hg in 96% of injection by 15 minute and in 100% by 30 minute. Eye with a hitory of glaucoma took longer to normalize the IOP (P = .002). tatitically ignificant IOP pike were oberved with a maller needle bore ize (P < .0001) and in eye with a hitory of glaucoma (P = .001). Concluion Elevation in IOP immediately after intravitreal injection are common, but are tranient. Prolonged monitoring of IOP may not be neceary on the day of injection in mot cae if hand movement viion, optic nerve perfuion, and lack of intraocular complication have been verified. However, cautiou monitoring hould be conidered in elect cae.