Title of article :
Effects of gemfibrozil administration on very low density lipoprotein receptor mRNA levels in rabbits
Author/Authors :
Naoki Matsuoka، نويسنده , , Hisato Jingami، نويسنده , , Hiroaki Masuzaki، نويسنده , , Megumi Mizuno، نويسنده , , Shigeo Nakaishi، نويسنده , , Junko Suga، نويسنده , , Tokuji Tanaka، نويسنده , , Tokuo Yamamoto، نويسنده , , Kazuwa Nakao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
To elucidate the regulation of very low density lipoprotein (VLDL) receptor gene expression, we administered to rabbits for 14 days gemfibrozil, a fibric acid derivative and a lipid lowering drug that is also included among peroxisome proliferators. VLDL receptor mRNA levels were examined by Northern blot analysis. The VLDL receptor mRNA levels in retroperitoneal adipose tissue and in gastrocnemius muscle were increased 6.9-fold and 3.7-fold, respectively, with gemfibrozil treatment, but no marked changes were observed in the heart, the organ in which VLDL receptor is most highly expressed. In the liver, VLDL receptor mRNA was not detected either before or after gemfibrozil administration. Lipoprotein lipase (LPL) and long-chain acyl coenzyme A synthetase (ACS) mRNA levels were also increased in parallel in adipose tissue. The enhanced expression of VLDL receptor mRNA may contribute to the increase of triglyceride-rich lipoprotein catabolism in peripheral tissues such as adipose tissue and muscles.
Keywords :
heparin , LDL , Glycosaminoglycans , lipoproteins , Sulfated polysaccharides , Fucosylated chondroitin sulfate , Fucans , Chondroitin 6-sulfate
Journal title :
Atherosclerosis
Journal title :
Atherosclerosis