Title of article :
Antiplatelet agent cilostazol potentiates adipocyte differentiation of 3T3-L1 cells
Author/Authors :
Takahisa Hirose، نويسنده , , Shogo Kurebayashi، نويسنده , , Soji Kasayama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
4
From page :
19
To page :
22
Abstract :
Cilostazol is an antiplatelet drug, which has beneficial effects in treatment of intermittent claudication and decreases serum triacyiglycerol level in these patients. In this study, we examined adipogenic potency of cilostazol using 3T3-L1 preadipocyte cell line because cilostazol is one of the tissue specific phosphodiesterase (PDE) inhibitors. Addition of cilostazol into the differentiation medium including insulin and dexamethasone, induced the adipocyte differentiation without isobutyl methylxanthine (IBMX). Compared with the cells incubated with vehicle, the cells treated with cilostazol contain much more lipid droplets in the cells 6 days after induction of differentiation. Adipocyte specific gene like stearoyl-CoA desaturase was strongly induced after addition of cilostazol. C/EBPβ, which is induced by IBMX was also induced by cilostazol. These findings suggest a possibility that adipogenic effect of cilostazol is one of the mechanisms, by which this agent decreases blood triacylglycerol level in the intermittent claudication patients.
Keywords :
Adipocyte differentiation , triacylglycerol , Phosphodiesterase , Cilostazol
Journal title :
Atherosclerosis
Serial Year :
2001
Journal title :
Atherosclerosis
Record number :
630468
Link To Document :
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