Title of article :
Placebo-controlled comparison between a single dose and a multidose of betamethasone in accelerating lung maturation of mice offspring, , ,
Author/Authors :
Jeffrey D. Stewart، نويسنده , , Anna E. Sienko، نويسنده , , Christina L. Gonzalez، نويسنده , , H. Dix Christensen، نويسنده , , William F. Rayburn، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
7
From page :
1241
To page :
1247
Abstract :
Objective: Our purpose was to determine, in a placebo-controlled manner with a mouse model, whether a multidose of betamethasone is more beneficial than a single dose in accelerating fetal lung maturation. Study Design: Ninety gravid CD-1 mice were randomly assigned to 1 of 3 groups (n = 30) to receive either a placebo (0.25 mL subcutaneously) or betamethasone (0.1 mg subcutaneously) as a single dose on gestational day 14 or as a multidose twice daily on gestational day 14 and 15. Ten pregnancies in each group were terminated at gestational day 16.5 to observe the neonatal breathing pattern (scale 0 to 5; 5 is unlabored breathing) and the lung histologic findings (scale 0 to 5; 5 is alveolar budding). The lungs of the offspring belonging to the remaining 20 pregnancies in each group were removed and weighed at postnatal day 1, 3, 5, or 120. Results: Fetuses exposed to a multidose of betamethasone displayed a higher breathing score at gestational day 16.5 than either to a single dose or to the placebo (mean score 4.6 vs 3.8 or 1.3; P< .001). Alveolar development was greater after exposure to a multidose of betamethasone than after a single dose or after a placebo (mean score 4.4 vs 3.5 or 1.6; P< .001). The lung weights at gestational day 16.5 were less after a multidose of betamethasone than after a single dose of either betamethasone or a placebo (18.3 ± 1.0 g vs 21.4 ± 1.3 g or 23.3 ± 1.3 g; P< .02). The lung/body weight ratio was similarly affected. This reduced weight of the lungs persisted postnatally into adulthood. Conclusions: With a CD-1 mouse model, a multidose of antenatal betamethasone accelerated fetal lung maturation more than after a single dose but was accompanied with a decrease in lung weight that persisted into adulthood. (Am J Obstet Gynecol 1998;179:1241-7.)
Keywords :
Betamethasone , corticosteroids , fetal maturation , fetal lung
Journal title :
American Journal of Obstetrics and Gynecology
Serial Year :
1998
Journal title :
American Journal of Obstetrics and Gynecology
Record number :
643033
Link To Document :
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