Maternal plasma leptin is increased in preeclampsia and positively correlates with fetal cord concentration, ,

Objective: We tested the hypothesis that the maternal leptin concentration would be increased in preeclampsia, independent of maternal obesity. Study Design: Maternal and cord plasma leptin concentrations were compared in 2 groups of women with either preeclampsia (n = 24) or normal pregnancy (n = 24), matched 1:1 for prepregnancy body mass index and fetal gestational age at sampling. Results: Median leptin concentrations were significantly higher (P< .03) in women with preeclampsia (45.6 ng/mL) than in normal pregnant women (27.0 ng/mL) and fell rapidly shortly after delivery (26.7 ng/mL and 25.4 ng/mL, respectively). Cord leptin was not significantly different between groups (5.4 ng/mL and 5.8 ng/mL, respectively). Maternal and cord leptin correlated significantly (ρ = 0.76, P< .01) only in preeclampsia. Conclusion: Preeclampsia is associated with an increase in maternal plasma leptin concentrations that strongly correlates with the fetal cord concentration at delivery. (Am J Obstet Gynecol 1999;180:731-6.)