Title of article :
Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: Findings from the initial screen of a randomized trial
Author/Authors :
Saundra S. Buys، نويسنده , , Edward Partridge، نويسنده , , Mark H. Greene، نويسنده , , Philip C. Prorok، نويسنده , , Douglas Reding، نويسنده , , Thomas L. Riley، نويسنده , , Patricia Hartge، نويسنده , , Richard M. Fagerstrom، نويسنده , , Lawrence R. Ragard، نويسنده , , David Chia، نويسنده , , Grant Izmirlian، نويسنده , , Mona Fouad، نويسنده , , Christine C. Johnson، نويسنده , , John K. Gohagan and for the PLCO Project Team، نويسنده ,
Abstract :
Objective
Ovarian cancer screening with transvaginal ultrasound (TVU) and CA-125 was evaluated in the Prostate, Lung, Colorectal and Ovarian (PLCO) Trial.
Study design
This was a randomized controlled trial of screening versus usual care. Baseline screening results are reported.
Results
Of 39,115 women randomized to receive screening, 28,816 received at least 1 test. Abnormal TVU was found in 1338 (4.7%), and abnormal CA-125 in 402 (1.4%). Twenty-nine neoplasms were identified (26 ovarian, 2 fallopian, and 1 primary peritoneal neoplasm). Nine were tumors of low malignant potential and 20 were invasive. The positive predictive value for invasive cancer was 3.7% for an abnormal CA-125, 1.0% for an abnormal TVU, and 23.5% if both tests were abnormal.
Conclusion
The effect of screening on ovarian cancer mortality in the PLCO cohort has yet to be evaluated and will require longer follow-up. Screening identified both early- and late-stage neoplasms, and the predictive value of both tests was relatively low.
