Title of article :
Circulating calcitonin gene-related peptide and its placental origins in normotensive and preeclamptic pregnancies
Author/Authors :
Yuan-Lin Dong، نويسنده , , Madhu Chauhan، نويسنده , , Kortney E. Green، نويسنده , , Sujatha Vegiraju، نويسنده , , Huiqun Wang، نويسنده , , Gary D.V. Hankins and The opinions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the U.S. Air Force or the Department of Defense.، نويسنده , , Chandra Yallampalli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
11
From page :
1657
To page :
1667
Abstract :
Objective The present study was designed to determine plasma calcitonin gene-related peptide concentration in both maternal and fetal circulations in normotensive and pre-eclamptic pregnancies and investigate whether placenta is 1 of its origins. Study design Maternal blood, cord blood, and villous tissue were collected from women in normotensive pregnancies and complicated with pre-eclampsia. Calcitonin gene-related peptide concentrations were determined by radioimmunoassay. Cellular localizations of calcitonin gene-related peptide messenger ribonucleic acid and protein expressions in placental villi were determined by in situ hybridization and immunohistochemistry. Results The following results were reached: (1) maternal plasma calcitonin gene-related peptide concentrations increased with advancing gestation but fell after delivery; (2) both maternal and cord plasma calcitonin gene-related peptide concentrations were positively correlated with the infant birth weights; (3) compared with normotensive pregnancies, calcitonin gene-related peptide levels in both maternal and cord plasma decreased in pregnancies with pre-eclampsia; (4) in normotensive pregnancies, the plasma calcitonin gene-related peptide of the umbilical vein was higher than the umbilical artery, but no significant differences between vein and artery in pre-eclampsia; (5) calcitonin gene-related peptide messenger ribonucleic acid and protein were expressed by syncytiotrophoblast cells and villous vascular endothelial cells in normotensive pregnancies, but only weak or absent staining was observed in pre-eclamptic placentas; and (6) calcitonin gene-related peptide is secreted by villous tissue in explant culture in a time-dependent manner, but less calcitonin gene-related peptide was produced by villous tissues from patients with pre-eclampsia. Conclusion Calcitonin gene-related peptide may play potential roles in maternal hemodynamic adaptation and fetal growth. Decreased circulating calcitonin gene-related peptide levels may be involved in maternal-fetal pathophysiology of pre-eclampsia. It is novel that placenta villous tissues might be one of the potential sources of calcitonin gene-related peptide during pregnancy.
Keywords :
Calcitonin generelatedpeptidePlacentaPregnancyPre-eclampsia
Journal title :
American Journal of Obstetrics and Gynecology
Serial Year :
2006
Journal title :
American Journal of Obstetrics and Gynecology
Record number :
645820
Link To Document :
بازگشت