Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension

Plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and E-selectin were measured in 80 outpatients with uncomplicated essential hypertension. Although the levels of E-selectin and sICAM-1 were similar between the patients with and without left ventricular (LV) hypertrophy, sVCAM-1 level was significantly elevated in the patients with LV hypertrophy (759.7 ± 154.6 ng/mL v 984.4 ± 240.6 ng/mL, P< .0001). The LV mass normalized to body surface area or height were significantly correlated with sVCAM-1 (r = 0.615, P< .0001 and R = 0.571, P< .0001, respectively). These results indicate that a soluble adhesion molecule is correlated with LV mass in uncomplicated essential hypertensive patients.