Author/Authors :
Koustubh Ranade، نويسنده , , David Hinds، نويسنده , , Chao Agnes Hsiung، نويسنده , , Lee-Ming Chuang، نويسنده , , Mau-Song Chang، نويسنده , , Ying-Tsung Chen، نويسنده , , Robert Pesich، نويسنده , , Joan Hebert، نويسنده , , Yii-Der I. Chen، نويسنده , , Victor Dzau، نويسنده , , Richard Olshen، نويسنده , , David Curb، نويسنده , , David Botstein، نويسنده , , David R. Cox، نويسنده , , Neil Risch، نويسنده ,
Abstract :
Abstract
Background
Our understanding of genes that predispose to essential hypertension is poor.
Methods
A genome-wide scan for linkage at 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low–normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).
Results
There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.
Conclusions
We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
