Title of article :
Effect of sodium on blood pressure, cardiac hypertrophy, and angiotensin receptor expression in rats
Author/Authors :
Zhiming Zhu، نويسنده , , Shanjun Zhu، نويسنده , , Ziqian Wu، نويسنده , , Daoyan Liu، نويسنده , , Yongjian Yang، نويسنده , , Xianmei Wang، نويسنده , , Jijin Zhu، نويسنده , , Martin Tepel، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Abstract :
Background
Sodium-induced hypertensive cardiac hypertrophy is related to pressure and volume overload.
Methods
Wistar rats were exposed to low and high sodium diet for 8 weeks. Angiotensin II receptor mRNA, abundance of p38 mitogen-activated protein kinase (p38MAPK), vasoconstriction of aortic rings, and angiotensin II-induced calcium increase were investigated.
Results
Rats on high sodium diet showed significantly elevated blood pressure. Heart weight, AT1 receptor mRNA in cardiac and aortic tissues, and abundance of p38MAPK were significantly increased in rats on high sodium diet.
Conclusions
Increased AT1 receptor expression and angiotensin II-induced calcium increase are compensatory effects in sodium-induced hypertension.
Keywords :
Angiotensin receptor , myocardium , sodium , Hypertension.
Journal title :
American Journal of Hypertension
Journal title :
American Journal of Hypertension